Cholesteryl γ-aminobutyrate

Cholesteryl γ-aminobutyrate is a γ-aminobutyric acid (GABA) -mimetic prodrug. Cholesteryl γ-aminobutyrate inhibits the orthodromically-evoked discharge of pyramidal cells in the CA1 region of the hippocampus. Cholesteryl γ-aminobutyrate suppresses the open-field activity of mice and rats in a dose-dependent manner and inhibits Bicuculline (HY-N0219) -induced seizures in mice. Cholesteryl γ-aminobutyrate can be used for the study of CNS diseases related to impaired GABAergic neuronal function[1].

Product Specifications

CAS Number

[89210-68-4]

Target

GABA Receptor

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OC(CCCN)=O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCCC(C)C)C

Molecular Formula

C31H53NO2

Molecular Weight

471.76

References & Citations

[1]Hesse GW, et al. Inhibitory effect of cholesteryl gamma-aminobutyrate on evoked activity in rat hippocampal slices. Neuropharmacology. 1985 Feb;24 (2) :139-46.