NVS1.1
NVS1.1 is a potent, orally active and brain-penetrant readthrough promoter. NVS1.1 triggers the degradation of eRF1 by activating the ribosome-related quality control pathways (involving GCN1, RNF14, and RNF25), thereby facilitating the reading through of premature termination codons. NVS1.1 can be used for the research of genetic diseases caused by nonsense mutations[1].
Product Specifications
UNSPSC
12352005
Target
Eukaryotic Initiation Factor (eIF)
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Smiles
N[C@H](C1=CC=CC=C1)C(C=C2S(=O)(C)=O)=C(C=C2C3=CC=NN3)Cl
Molecular Formula
C17H16ClN3O2S
Molecular Weight
361.85
References & Citations
[1]Gurzeler LA, et al. Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control. Cell Rep. 2023 Sep 26;42 (9) :113056.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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