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NEK7 degrader-2

NEK7 degrader-2 (Compound 25) is a NEK7 degrader. NEK7 degrader-2 shows dose-dependent NEK7 degradation ability in human PBMC-derived macrophages. NEK7 degrader-2 reduce the release level of pro-inflammatory cytokines IL-1β induced by NLRP3 inflammasome activation. NEK7 degrader-2 can be used for the study of inflammatory diseases[1].

Product Specifications

CAS Number

3037413-54-7

UNSPSC

12352005

Target

Interleukin Related; NEKs; NOD-like Receptor (NLR)

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

O=C1NC(C(CC1)N2C(C3=CC=C(C4NCCCC4)C=C3C2C)=O)=O

Molecular Formula

C19H23N3O3

Molecular Weight

341.40

References & Citations

[1]COTTENS, et al. NEK7 DEGRADERS AND METHODS OF USE THEREOF. WO 2024/096753 A1. World Intellectual Property Organization (WIPO) . 10.05.2024

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IL-1; NEK7; NLRP3

Frequently Asked Questions

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