NEK7 degrader-2
NEK7 degrader-2 (Compound 25) is a NEK7 degrader. NEK7 degrader-2 shows dose-dependent NEK7 degradation ability in human PBMC-derived macrophages. NEK7 degrader-2 reduce the release level of pro-inflammatory cytokines IL-1β induced by NLRP3 inflammasome activation. NEK7 degrader-2 can be used for the study of inflammatory diseases[1].
Product Specifications
CAS Number
[3037413-54-7]
UNSPSC
12352005
Target
Interleukin Related; NEKs; NOD-like Receptor (NLR)
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O=C1NC(C(CC1)N2C(C3=CC=C(C4NCCCC4)C=C3C2C)=O)=O
Molecular Formula
C19H23N3O3
Molecular Weight
341.40
References & Citations
[1]COTTENS, et al. NEK7 DEGRADERS AND METHODS OF USE THEREOF. WO 2024/096753 A1. World Intellectual Property Organization (WIPO) . 10.05.2024
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; NEK7; NLRP3
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