AV5116

AV5116 is a cap-dependent endonuclease inhibitor (CENI) that binds to the active site of the cap-dependent endonuclease (CEN) located in the N-terminal domain of the polymerase acidic. AV5116 exhibits potent inhibitory activity against influenza viruses (influenza A, B, and C viruses) . AV5116 can be used for the study of influenza virus infections[1].

Product Specifications

CAS Number

[2417851-90-0]

UNSPSC

12352005

Target

Endonuclease; Influenza Virus

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Purity

99.57

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1C(N(C=C2)N([C@]3([H])C4=C(SCC5=C(F)C(F)=CC=C53)C=CS4)[C@@]6([H])N1CCOC6)=C(O)C2=O

Molecular Formula

C22H17F2N3O4S2

Molecular Weight

489.51

References & Citations

[1]Chesnokov A, et al. Influenza C virus susceptibility to antivirals with different mechanisms of action. Antimicrob Agents Chemother. 2024 May 2;68 (5) :e0172723.