Fmoc-Val-Cit-PAB-Exatecan
Fmoc-Val-Cit-PAB-Exatecan is a Drug-linker conjugate for ADC. Fmoc-Val-Cit-PAB-Exatecan contains the ADC linker (Fmoc-Val-Cit-PAB) and a DNA topoisomerase I inhibitor Exatecan (HY-13631) [1].
Product Specifications
CAS Number
[2754384-69-3]
UNSPSC
12352005
Target
Drug Derivative; Drug-Linker Conjugates for ADC; Topoisomerase
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
FC(C=C(N=C1C2=CC3=C4COC([C@](CC)3O)=O)C5=C6CC[C@H](NC(OCC7=CC=C(NC([C@@H](NC([C@@H](NC(OCC8C9=CC=CC=C9C%10=CC=CC=C%108)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C7)=O)C5=C1CN2C4=O)=C6C
Molecular Formula
C58H59FN8O11
Molecular Weight
1063.13
References & Citations
[1]Xiao Shang, et al. Linkers, drug linkers and conjugates thereof and methods of using the same. WO2023280227A2. 2023-12-01.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Topo I
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