DBCO-PEG3-GGFG-Exatecan
DBCO-PEG3-GGFG-Exatecan is a Drug-linker conjugate for ADC. DBCO-PEG3-GGFG-Exatecan contains the ADC linker (DBCO-PEG3-GGFG) and a DNA topoisomerase I inhibitor Exatecan (HY-13631) [1].
Product Specifications
CAS Number
[2754384-71-7]
UNSPSC
12352005
Target
Drug Derivative; Drug-Linker Conjugates for ADC; Topoisomerase
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCCOCCOCCOCCC(NCC(NCC(N[C@@H](CC4=CC=CC=C4)C(NCC(N[C@@H]5C6=C7C(C(N8C7)=CC([C@](O)(C(OC9)=O)CC)=C9C8=O)=NC%10=CC(F)=C(C)C(CC5)=C%106)=O)=O)=O)=O)=O)=O
Molecular Formula
C67H70FN9O14
Molecular Weight
1244.32
References & Citations
[1]CHUANG, Shih-Hsien, et al. Antibody-drug conjugates containing an anti-mesothelin antibody and uses thereof. WO2021248048 A2. 2021-12-09.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Topo I
Curated Selection
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