IRAK4 modulator-2
IRAK4 modulator-2 (Compound 5) is a selective dual Interleukin-1 Receptor Associated Kinase 4 (IRAK4) and IRAK1 inhibitor with IC50 values of 0.005 μM and 0.97 μM, erespectively. IRAK4 modulator-2 blocks IRAK-mediated signaling pathways (e.g., JAK-STAT, NF-κB pathways), reduces the production of pro-inflammatory cytokines (e.g., IL-1, TNF), and exerts anti-inflammatory activity. IRAK4 modulator-2 is promising for research of autoimmune diseases and inflammatory diseases, such as rheumatoid arthritis, psoriasis, inflammatory bowel disease[1].
Product Specifications
CAS Number
[1356013-27-8]
UNSPSC
12352005
Target
IRAK; JAK; NF-κB; STAT
Related Pathways
Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Purity
99.86
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=C2N=CC=CN2N=C1)NC3=CC(Cl)=CC=C3N4CCC(C(C)O)CC4
Molecular Formula
C20H22ClN5O2
Molecular Weight
399.87
References & Citations
[1]Nidhi Arora, et al. Pyrazolo [1, 5a] pyrimidine and thieno [3, 2b] pyrimidine derivatives as irak4 modulators. WO2012007375A1. 2012-01-19.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK1; IRAK4
Available Sizes
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