KRAS G12D-IN-30
KRAS G12D-IN-30 (Compound 4) is a KRAS inhibitor. KRAS G12D-IN-30 inhibits the activation of the downstream MAPK signaling cascade (Raf1-MEK-ERK) by blocking the activity of the KRAS G12 mutant. KRAS G12D-IN-30 can be used for the research of cancer[1].
Product Specifications
CAS Number
[3022287-75-5]
UNSPSC
12352005
Target
ERK; MEK; p38 MAPK; Raf; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Cancer
Purity
99.3800
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=C(N2CC3(C2)CCC(S4)=C3C(C#N)=C4N)N=C(OCC5(CC5)CN6CCOCC6)N=C1N7C[C@H]8N[C@H](CC8)C7
Molecular Formula
C30H37N9O2S
Molecular Weight
587.74
References & Citations
[1]Hong Lin, et al. Pyrimidine based modulators and uses thereof. WO2023230190A1. 2023-11-30
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Available Sizes
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