BBL454
BBL454 (Compound 43) is a Cholecystokinin 2B (CCK2B) receptor agonist. BBL454 induces hyperactivity and improves memory in rat models while it has weak activity on the peripheral CCK2 receptor and no anxiogenic activity. BBL454 increases gastric acid output in anesthetised rat models. BBL454 can be used for diabetes research[1][2].
Product Specifications
UNSPSC
12352211
Target
Cholecystokinin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Metabolic Disease
Smiles
CCCCCCC(CC(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N(C)[C@@H](CCCC)C(N[C@@H](CC(O)=O)C(N[C@@H](CC3=CC=CC=C3)C(N)=O)=O)=O)=O)=O)=O
Molecular Formula
C40H54N6O8
Molecular Weight
746.89
References & Citations
[1]Kalindjian SB, et al. Strategies for the design of non-peptide CCK2 receptor agonist and antagonist ligand. Curr Top Med Chem. 2007;7 (12) :1195-204. |[2]Bellier B, et al. New CCK2 agonists confirming the heterogeneity of CCK2 receptors: characterisation of BBL454. Naunyn Schmiedebergs Arch Pharmacol. 2004 Nov;370 (5) :404-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCKBR
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