Otviciclib
Otviciclib (Compound 86) is a CDK inhibitor. Otviciclib has potent anti-proliferative activity against solid tumor cells (such as HCT116, NCIH82 and DU145 cells) with no significant toxicity to normal cells, and effectively induces the G2/M phase cells arrest and apoptosis. Otviciclib has a broad-spectrum anticancer activity, such as colon, pancreatic and lung cancer[1].
Product Specifications
CAS Number
[2228039-87-8]
UNSPSC
12352005
Target
Apoptosis; CDK
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1N=C(CC2=CC=C(NC(CN(CC)CC)=O)C=C2)NC3=C1C(N(C)C)=NN3C4=C(C=C(S(=O)(N)=O)C=C4Cl)Cl
Molecular Formula
C26H30Cl2N8O4S
Molecular Weight
621.54
References & Citations
[1]Wunderlich W, et al. 3-amino-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-ones as cyclin dependent kinase inhibitors. WO2018099952A1. 2018-06-07.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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