M1 mAChR modulator-1

M1 mAChR modulator-1 (Example 66) is a muscarinic M1 receptor (mAChR1) positive allosteric modulator. M1 mAChR modulator-1 effectively promotes gastrointestinal motility and defecation in mouse models with low central permeability. M1 mAChR modulator-1 can be used for constipation research[1].

Product Specifications

CAS Number

[2247999-07-9]

UNSPSC

12352005

Target

MAChR

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(C(C=CC(CC(C=C1C(N=CN(C1=O)[C@H]2CCOC[C@@H]2O)=C3C)=C3C)=C4)=C4F)NCCOC

Molecular Formula

C26H30FN3O5

Molecular Weight

483.53

References & Citations

[1]Sakai S, et al. Heterocyclic compounds useful as modulators of acetylcholine receptors. WO2018194181A1. 2019-03-21. |[2]Sakai S, et al. Heterocyclic compounds useful as modulators of acetylcholine receptors. WO2018194181A1. 2019-03-21.