M1 mAChR modulator-1
M1 mAChR modulator-1 (Example 66) is a muscarinic M1 receptor (mAChR1) positive allosteric modulator. M1 mAChR modulator-1 effectively promotes gastrointestinal motility and defecation in mouse models with low central permeability. M1 mAChR modulator-1 can be used for constipation research[1].
Product Specifications
CAS Number
2247999-07-9
UNSPSC
12352005
Target
MAChR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C(C=CC(CC(C=C1C(N=CN(C1=O)[C@H]2CCOC[C@@H]2O)=C3C)=C3C)=C4)=C4F)NCCOC
Molecular Formula
C26H30FN3O5
Molecular Weight
483.53
References & Citations
[1]Sakai S, et al. Heterocyclic compounds useful as modulators of acetylcholine receptors. WO2018194181A1. 2019-03-21. |[2]Sakai S, et al. Heterocyclic compounds useful as modulators of acetylcholine receptors. WO2018194181A1. 2019-03-21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR1
Available Sizes
Frequently Asked Questions
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