SSTR3 agonist-1 (TFA)
SSTR3 agonist-1 TFA is a potent, orally active, and selective SSTR3 agnoist (EC50 =0.14 nM) . SSTR3 agonist-1 TFA binds to SSTR3 receptor to inhibit cAMP activity. SSTR3 agonist-1 TFA decreases kidney weight and kidney cystic index (KCI) in a mouse model of autosomal dominant polycystic kidney disease (ADPKD) . SSTR3 agonist-1 TFA can be used for ADPKD research[1].
Product Specifications
UNSPSC
12352005
Target
Somatostatin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Purity
98.86
Smiles
O=C(C1=C(N=C2C=C(C(OC)=CC2=C1N3CC[C@H](C)NCC3)C(F)(F)F)N4CCOCC4)N[C@@H](C)C5=CC(OC)=C(F)C=C5.O=C(O)C(F)(F)F
Molecular Formula
C33H38F7N5O6
Molecular Weight
733.67
References & Citations
[1]Kim S. H., et al. Somatostatin Subtype Receptor 3 (SSTR3) Agonists and Uses Thereof. WO2025111318A1. 2025-05-30.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SSTR3
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