OART

OART (Oxaliplatin-artesunate) is a ferroptosis inducer. OART significantly inhibits tumor cell proliferation. OART induces cytoplasmic and mitochondrial LPO to promote tumor ferroptosis, via destroying glutathione-mediated ferroptosis defense system and enhancing iron-dependent Fenton reaction. OART enhances tumor immunogenicity, transforming tumor environment from immunosuppressive to immunosensitive. OART has strong tumor regression in tumor-bearing mouse models. OART can be used for cancer immunotherapy research[1].

Product Specifications

Product Name Alternative

Oxaliplatin-artesunate

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase; Ferroptosis; Glutathione Peroxidase; Mitochondrial Metabolism; MMP; Transferrin Receptor

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

[OH-][Pt+4]12([O-]C(C([O-]2)=O)=O)(OC(CCC(O[C@@H]([C@@H]([C@@]3(CC[C@H]([C@@]4(CC5)[H])C)[H])C)O[C@](O[C@]65C)([C@]34OO6)[H])=O)=O)[NH2][C@@]7([H])[C@](CCCC7)([H])[NH2]1

Molecular Formula

C27H42N2O13Pt+

Molecular Weight

797.71

References & Citations

[1]Fan R, et al. A platinum (IV) -artesunate complex triggers ferroptosis by boosting cytoplasmic and mitochondrial lipid peroxidation to enhance tumor immunotherapy. MedComm (2020) . 2024 May 20;5 (6) :e570.