OART
OART (Oxaliplatin-artesunate) is a ferroptosis inducer. OART significantly inhibits tumor cell proliferation. OART induces cytoplasmic and mitochondrial LPO to promote tumor ferroptosis, via destroying glutathione-mediated ferroptosis defense system and enhancing iron-dependent Fenton reaction. OART enhances tumor immunogenicity, transforming tumor environment from immunosuppressive to immunosensitive. OART has strong tumor regression in tumor-bearing mouse models. OART can be used for cancer immunotherapy research[1].
Product Specifications
Product Name Alternative
Oxaliplatin-artesunate
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase; Ferroptosis; Glutathione Peroxidase; Mitochondrial Metabolism; MMP; Transferrin Receptor
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
Molecular Formula
C27H42N2O13Pt+
Molecular Weight
797.71
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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