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Basivarsen

Basivarsen (DYNE-101 oligomer) is composed of an antisense oligonucleotides and a linker (HY-177454) . It is designed to target mutant nuclear myotonic dystrophy protein kinase (DMPK) RNA for RHase H-mediated degradation to correct splicing. It is used for the study of myotonic dystrophy type 1 (DM1) .

Product Specifications

CAS Number

[3028750-61-7]

Product Name Alternative

DYNE-101 oligomer

UNSPSC

12352005

Target

Antibody-Oligonucleotide Conjugates (AOCs)

Related Pathways

Antibody-drug Conjugate/ADC Related

Field of Research

Others

Smiles

[Basivarsen]

Molecular Formula

C228H317N70O107P16S15

Molecular Weight

6726.91

References & Citations

[1]Weeden T, Picariello T, Quinn B, et al. FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models. Commun Med (Lond) . 2025;5 (1) :22.

Shipping Conditions

Room temperature

Scientific Category

Oligonucleotides

Clinical Information

Phase 2

Curated Selection

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