Apicidin C
Apicidin C (Compound 5a) is a cyclic tetrapeptide. Apicidin C has an antiprotozoal and antimalarial activity against Eimeria tenella (IC50: 6 nM) by reversibly inhibiting HDAC acyivity. Apicidin C can be used for malaria infections research[1].
Product Specifications
CAS Number
[366448-28-4]
UNSPSC
12352005
Target
HDAC; Parasite
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Infection
Smiles
CON1C2=CC=CC=C2C(C[C@H]3C(N[C@H](C(N4[C@@](CCCC4)([H])C(N[C@H](C(N3)=O)CCCCCC(CC)=O)=O)=O)C(C)C)=O)=C1
Molecular Formula
C33H47N5O6
Molecular Weight
609.76
References & Citations
[1]Singh SB, et al. Structure, histone deacetylase, and antiprotozoal activities of apicidins B and C, congeners of apicidin with proline and valine substitutions. Org Lett. 2001 Sep 6;3 (18) :2815-8.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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