NLRP3 modulator 8
NLRP3 modulator 8 (Compound 14) is a NLRP3 modulator. NLRP3 modulator 8 significantly degrades NEK7 with an DC50 of 9 nM. NLRP3 modulator 8 dose-dependently inhibits caspase-1 activity and IL-1β release in macrophages in response to NLRP3 inflammasome activation. NLRP3 modulator 8 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research[1].
Product Specifications
CAS Number
[3069891-88-6]
UNSPSC
12352005
Target
Caspase; Interleukin Related; NEKs; NOD-like Receptor (NLR)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Smiles
O=C1NC(C(CC1)C2=C(C=C(CNC(C(C)(C)C3=NC=C(C=N3)F)=O)C=C2Cl)Cl)=O
Molecular Formula
C20H19Cl2FN4O3
Molecular Weight
453.29
References & Citations
[1]Liardo E, et al. Substituted piperidinediones for targeted protein degradation. WO2025024521A1. 2025-01-30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 1; IL-1; NEK7
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