TMX-4140
TMX-4140 is a selective PIP4K2C inhibitor with a KD of 7.2 nM for PIP4K2C over PIP4K2B. TMX-4140 can be used for synthesis of PROTAC TMX-4153.
Product Specifications
CAS Number
2867519-51-3
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; PIKfyve
Related Pathways
PI3K/Akt/mTOR; PROTAC
Field of Research
Cancer
Smiles
ClC1=CN=C(N=C1C2=CC=CC(C3=CC=CC=C3)=C2)NC4=CC(N5CCCC5=O)=CN=C4
Molecular Formula
C25H20ClN5O
Molecular Weight
441.91
References & Citations
[1]Teng M, et al. Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader. Angew Chem Int Ed Engl. 2023 Apr 24;62 (18) :e202302364.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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