VR11 aptamer
VR11 aptamer is a DNA-based TNF-α inhibitor with a KD of 7.0 nM. VR11 aptamer prevents TNFα-induced apoptosis and NO production. VR11 aptamer has non-immunogenicity and does not raise immune responses when injected intraperitoneally into C57BL/6 mice model. VR11 aptamer can be used for inflammatory diseases research[1].
Product Specifications
UNSPSC
12352208
Target
Apoptosis; NO Synthase; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
[VR11aptamer]
References & Citations
[1]Orava EW, et al. A short DNA aptamer that recognizes TNFα and blocks its activity in vitro. ACS Chem Biol. 2013 Jan 18;8 (1) :170-8.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Curated Selection
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