SV119 (hydrochloride)

SV119 hydrochloride is a sigma-2 ligand with a Ki value of 5.2 nM. SV119 hydrochloride enhances the efficient transport of drugs across the plasma membrane of cancer cells. The conjugation of dm-Erastin with SV119 hydrochloride successfully overcomes the internalization barrier observed in pancreatic cancer, while preserving the inherent anti-tumor activity of Erastin (HY-15763) . Additionally, SV119 hydrochloride demonstrates cytotoxic effects on triple-negative breast cancer (TNBC) cells and induces apoptosis[1][2].

Product Specifications

CAS Number

[913816-12-3]

UNSPSC

12352005

Target

Apoptosis; Sigma Receptor

Related Pathways

Apoptosis; Neuronal Signaling

Field of Research

Cancer

Smiles

NCCCCCCN([C@@]1([H])C2)[C@](CCC1)([H])C[C@H]2OC(NC(C=C3C)=C(C=C3)OC)=O.Cl.Cl

Molecular Formula

C23H39Cl2N3O3

Molecular Weight

476.48

References & Citations

[1]Takchi R, et al. Cytotoxic sigma-2 ligands trigger cancer cell death via cholesterol-induced-ER-stress. Cell Death Dis. 2024 May 2;15 (5) :309.|[2]Zongyi Liu, et al. Abstract 5428: Sigma-2 receptor-induced cell death: a novel approach to triple-negative breast cancer treatment. Cancer Res (2015) 75 (15_Supplement) : 5428.