N-Didesmethyladitoprim

N-Didesmethyladitoprim is a metabolite of Aditoprime (HY-139743) . Aditoprime is a selective bacterial dihydrofolate reductase (DHFR) inhibitor with IC50s of 47 and 520 nM for E.coli and L.casei DHFR , respectively. Aditoprime inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime has a broad-spectrum antibacterial activity and excellent pharmacokinetics[1][2][3][4].

Product Specifications

CAS Number

[56066-19-4]

Product Name Alternative

N-Didesmethyl-ADP

UNSPSC

12352005

Target

Antifolate; Bacterial; Drug Metabolite

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

NC1=NC=C(CC2=CC(OC)=C(C(OC)=C2)N)C(N)=N1

Molecular Formula

C13H17N5O2

Molecular Weight

275.31

References & Citations

[1]Then RL, et al. Properties of aditoprim, a new antibacterial dihydrofolate reductase inhibitor. Zentralbl Veterinarmed B. 1988 Feb;35 (2) :114-20.|[2]Cheng G, et al. The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis. Sci Rep. 2017 Feb 1;7:41370.|[3]Wang X, et al. Two-generation reproduction and teratology studies of feeding aditoprim in Wistar rats. J Appl Toxicol. 2015 Dec;35 (12) :1531-8. |[4]Wang L, et al. Metabolism and Disposition of Aditoprim in Swine, Broilers, Carp and Rats. Sci Rep. 2016 Feb 3;6:20370.