BTT-3034

BTT-3034, a sulfonamide derivative, is an α2β1 integrin inhibitor. BTT-3034 inhibits cell adhesion to rat tail collagen I with an EC50 of 160 nM and a corresponding Emaxof 86%. BTT-3034 inhibits collagen binding by an α2 variant carrying the conformationally activating E318W mutation[1].

Product Specifications

CAS Number

[1259029-47-4]

UNSPSC

12352100

Target

Integrin

Related Pathways

Cytoskeleton

Field of Research

Cardiovascular Disease

Smiles

O=C(NC1=CC=C(N(S(=O)(C2=CC=C(C3=CC=NN3C)S2)=O)C)C=C1)NC4=CC=CC=C4

Molecular Formula

C22H21N5O3S2

Molecular Weight

467.56

References & Citations

[1]Nissinen L, et al. Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation. J Biol Chem. 2012 Dec 28;287 (53) :44694-702.