U-80125

U80215, a dansylated peptide, is a competitive human renin inhibitor with the IC50 of 2.3 μM. U80215 shows excitation and emission maxima at 340 and 530 nm[1].

Product Specifications

CAS Number

[123300-09-4]

UNSPSC

12352100

Target

Renin

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

O=C([C@H]([C@H](CC)C)NC([C@H](C(C)C)CC([C@H](CC(C)C)NC([C@H](CC1=CN=CN1)NS(=O)(C2=CC=CC3=C(N(C)C)C=CC=C32)=O)=O)O)=O)NCC4=NC=CC=C4

Molecular Formula

C42H60N8O6S

Molecular Weight

805.04

References & Citations

[1]Epps DE, et al. An experimental method for the determination of enzyme-competitive inhibitor dissociation constants from displacement curves: application to human renin using fluorescence energy transfer to a synthetic dansylated inhibitor peptide. Anal Biochem. 1989 Aug 15;181 (1) :172-81.