Ciprokiren
Ciprokiren (Ro 44-9375) is a Renin inhibitor with IC50s of 0.07 and 0.65 nM for hRenin in buffer and plasma, respectively. Ciprokiren be applied transdermally with similar hemodynamic effects without decrease of plasma renin activity or plasma immunoreactive angiotensin II. Ciprokiren has antihypertensive efficacy and can be used for hypertension research[1].
Product Specifications
CAS Number
[143631-62-3]
Product Name Alternative
Ro 44-9375
UNSPSC
12352100
Target
Renin
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
O=C(N1CCOCC1)C(C)(C)S(C[C@@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@H]([C@@H](O)[C@H](C3CC3)O)CC4CCCCC4)=O)CC5=CN=CN5)=O)(=O)=O
Molecular Formula
C37H55N5O8S
Molecular Weight
729.93
References & Citations
[1]Fischli W, et al. Ciprokiren (Ro 44-9375) . A renin inhibitor with increasing effects on chronic treatment. Hypertension. 1994 Aug;24 (2) :163-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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