Anti-inflammatory agent 105

Anti-inflammatory agent 105 (Compound 12) is an anti-inflammatory compound. The IC50 of Anti-inflammatory agent 105 for the inhibition of TNF-α synthesis and release in the human macrophage cell line U937 is 0.124 nM[1].

Product Specifications

CAS Number

[382630-14-0]

UNSPSC

12352100

Target

TNF Receptor

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C(C1=CC=CO1)O[C@]2([C@@]3([C@@]([C@@]4([H])[C@]([C@H](C3)O)([C@@]5(C([C@H](C4)F)=CC(C=C5)=O)C)Cl)([H])C[C@H]2C)C)C(OC)=O

Molecular Formula

C27H30ClFO7

Molecular Weight

520.97

References & Citations

[1]Sandham DA, et al. Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters. Bioorg Med Chem. 2004 Oct 1;12 (19) :5213-24.