HCV NS5B polymerase-IN-3

HCV NS5B polymerase-IN-3 (Compound 30a) is an inhibitor of the HCV NS5B polymerase. HCV NS5B polymerase-IN-3 exhibits anti-HCV activity in the Huh7 replicon cell line with an EC50 of 0.23 μM and shows no obvious cytotoxicity. HCV NS5B polymerase-IN-3 can be used in research related to the hepatitis C virus[1].

Product Specifications

CAS Number

[1255860-45-7]

UNSPSC

12352005

Target

HCV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O[C@H]1[C@]2(CCO2)[C@H](N(C=CC3=O)C(N3)=O)O[C@@H]1CO[P](OC4=CC=CC=C4)(N[C@@H](C)C(OCC(C)C)=O)=O

Molecular Formula

C24H32N3O10P

Molecular Weight

553.50

References & Citations

[1]Jonckers TH, et al. Nucleotide prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides as novel inhibitors of the HCV NS5B polymerase. J Med Chem. 2014 Mar 13;57 (5) :1836-44.