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PDE5-IN-15

PDE5-IN-15 (compound 21) is a xanthine derivative and PDE5 inhibitor, with IC50 values of 0.002, 0.180, 2.85 and 2.22 μM against hPDE5, bPDE6, bPDE1 and hPDE3, respectively. PDE5-IN-15 has good oral bioavailability in dogs. PDE5-IN-15 can be used in research on male erectile dysfunction[1].

Product Specifications

CAS Number

366444-83-9

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Smiles

COC(C=C12)=CC=C1C=NC=C2CC3=NC(N(C(N(C4=O)C)=O)CC(C)C)=C4N3

Molecular Formula

C21H23N5O3

Molecular Weight

393.44

References & Citations

[1]Arnold NJ, et al. Potent and selective xanthine-based inhibitors of phosphodiesterase 5. Bioorg Med Chem Lett. 2007 Apr 15;17 (8) :2376-9.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PDE1; PDE3; PDE5; PDE6

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