PDE5-IN-15
PDE5-IN-15 (compound 21) is a xanthine derivative and PDE5 inhibitor, with IC50 values of 0.002, 0.180, 2.85 and 2.22 μM against hPDE5, bPDE6, bPDE1 and hPDE3, respectively. PDE5-IN-15 has good oral bioavailability in dogs. PDE5-IN-15 can be used in research on male erectile dysfunction[1].
Product Specifications
CAS Number
[366444-83-9]
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Smiles
COC(C=C12)=CC=C1C=NC=C2CC3=NC(N(C(N(C4=O)C)=O)CC(C)C)=C4N3
Molecular Formula
C21H23N5O3
Molecular Weight
393.44
References & Citations
[1]Arnold NJ, et al. Potent and selective xanthine-based inhibitors of phosphodiesterase 5. Bioorg Med Chem Lett. 2007 Apr 15;17 (8) :2376-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE1; PDE3; PDE5; PDE6
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