LCZ960

LCZ960 is an orally active glucokinase (GK) activator. LCZ960 stimulates GK activity in hepatocytes in vitro and stimulates glucose uptake in vivo through hepatic GK activation. LCZ960 lowers blood glucose in mice with diet-induced obesity (DIO) . LCZ960 maintains normoglycemia and improves glucose tolerance in DIO mice and rats. LCZ960 stimulates glycogen synthase flux and increases hepatic glycogen turnover in rats. LCZ960 induces increased hepatic glycogen recycling. LCZ960 can be used to study high-fat diet-induced obesity and type 2 diabetes[1].

Product Specifications

CAS Number

1067877-83-1

Product Name Alternative

NVP-LCZ960

UNSPSC

12352005

Target

Glucokinase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=S(C(C=C1)=CC=C1[C@@H](CC2CCCC2)C(NC3=NC4=CC=C(C5=CC=NC=C5)N=C4S3)=O)(N6CCN(CC6)C)=O

Molecular Formula

C30H34N6O3S2

Molecular Weight

590.76

References & Citations

[1]Laurent D, et al. Hepatic glycogen cycling contributes to glucose lowering effects of the glucokinase activator LCZ960. Eur J Pharmacol. 2013 Sep 5;715 (1-3) :89-95.