NVP-BQS481
NVP-BQS481 (Compound 1) is a selective Kinesin spindle protein-5 (Eg5) inhibitor with an IC50IC50: 0.0.9 nM for SK-OV-3ip cells) . NVP-BQS481 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
1161925-41-2
UNSPSC
12352005
Target
ADC Payload; Kinesin
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
FC[C@@H](N)CCN(C(CO)=O)[C@H](C(C)(C)C)C1=NC(C2=C(F)C=CC(F)=C2)=CN1CC3=CC=CC=C3
Molecular Formula
C27H33F3N4O2
Molecular Weight
502.57
References & Citations
[1]Karpov AS, et al. Discovery of Potent and Selective Antibody-Drug Conjugates with Eg5 Inhibitors through Linker and Payload Optimization. ACS Med Chem Lett. 2019 Dec 3;10 (12) :1674-1679.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Kinesin-5/Eg5/KSP
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