NVP-BQS481

NVP-BQS481 (Compound 1) is a selective Kinesin spindle protein-5 (Eg5) inhibitor with an IC50IC50: 0.0.9 nM for SK-OV-3ip cells) . NVP-BQS481 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

[1161925-41-2]

UNSPSC

12352005

Target

ADC Payload; Kinesin

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

FC[C@@H](N)CCN(C(CO)=O)[C@H](C(C)(C)C)C1=NC(C2=C(F)C=CC(F)=C2)=CN1CC3=CC=CC=C3

Molecular Formula

C27H33F3N4O2

Molecular Weight

502.57

References & Citations

[1]Karpov AS, et al. Discovery of Potent and Selective Antibody-Drug Conjugates with Eg5 Inhibitors through Linker and Payload Optimization. ACS Med Chem Lett. 2019 Dec 3;10 (12) :1674-1679.