SST1 receptor antagonist-1

SST1 receptor antagonist-1 (Compound 23) is a selective Somatostatin receptor 1 (SST1) antagonist with pKds of 9.11 and 8.79 for rSST1 and hSST1, respectively. SST1 receptor antagonist-1 can be used for retinal and endocrine dysfunctions, cancer and neuropsychiatric disorders research[1].

Product Specifications

CAS Number

[868057-23-2]

UNSPSC

12352005

Target

Somatostatin Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cancer; Endocrinology; Neurological Disease

Smiles

O=C(CCN(CCC1C2=C(OC3=C1C=CC=C3)C=CC=C2)C)N4CCN(CC4)C5=CC=C(C(F)=C5)F

Molecular Formula

C29H31F2N3O2

Molecular Weight

491.57

References & Citations

[1]Troxler T, et al. Discovery of novel non-peptidic beta-alanine piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst1 receptor antagonists. Bioorg Med Chem Lett. 2009 Mar 1;19 (5) :1305-9.