HM5023507
HM5023507 is an orally active and selective PI3Kδ/γ inhibitor with IC50s of 4 and 5 μM for PI3Kδ and PI3Kγ over PI3Kβ and PI3Kα. HM5023507 attenuates the PI3Kδ/γ signaling in human basophils. HM5023507 also attenuates the activation and function of human B and T cells and cytokine and IgG production during cocultures, and Th17 differentiation of CD4 T cells. HM5023507 inhibited semiestablished collagen-induced arthritic inflammation in the rat models. HM5023507 can be used for inflammatory diseases like rheumatoid arthritis research[1].
Product Specifications
CAS Number
1549766-06-4
UNSPSC
12352005
Target
PI3K
Related Pathways
PI3K/Akt/mTOR
Field of Research
Inflammation/Immunology
Smiles
O=C1N(C2=CC=CC=C2)C([C@H]3N(C4=NC(N)=NC=C4C(C)=O)CC3)=NN5C1=C(C=C5)Cl
Molecular Formula
C21H18ClN7O2
Molecular Weight
435.87
References & Citations
[1]Cai Y, et al. Immunological characterization of HM5023507, an orally active PI3Kδ/γ inhibitor. Pharmacol Res Perspect. 2020 Jan 13;8 (1) :e00559.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
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