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FGFR-IN-22

FGFR-IN-22 (Compound 23) is a FGFR inhibitor with IC50s of 0.631, 1.26, 0.851 and 1 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. FGFR-IN-22 effectively inhibits cell proliferation that depends on the FGFR1 and FGFR3 signaling pathway. FGFR-IN-22 can be used for cancers such as chronic lymphocytic leukemia (CLL) research[1].

Product Specifications

CAS Number

1431872-18-2

UNSPSC

12352005

Target

FGFR

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

FC1=C(N(CC2=NC=CN2)C3=NC4=NC(C5=CN(C)N=C5)=CN=C4C=C3)C=C(OC)C=C1OC

Molecular Formula

C23H21FN8O2

Molecular Weight

460.46

References & Citations

[1]Berdini V, et al. Anticancer pyridopyrazines via the inhibition of fgfr kinases. WO2013061080A1. 2013-05-02.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

FGFR1; FGFR2; FGFR3; FGFR4

Frequently Asked Questions

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