FGFR-IN-22
FGFR-IN-22 (Compound 23) is a FGFR inhibitor with IC50s of 0.631, 1.26, 0.851 and 1 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. FGFR-IN-22 effectively inhibits cell proliferation that depends on the FGFR1 and FGFR3 signaling pathway. FGFR-IN-22 can be used for cancers such as chronic lymphocytic leukemia (CLL) research[1].
Product Specifications
CAS Number
1431872-18-2
UNSPSC
12352005
Target
FGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
FC1=C(N(CC2=NC=CN2)C3=NC4=NC(C5=CN(C)N=C5)=CN=C4C=C3)C=C(OC)C=C1OC
Molecular Formula
C23H21FN8O2
Molecular Weight
460.46
References & Citations
[1]Berdini V, et al. Anticancer pyridopyrazines via the inhibition of fgfr kinases. WO2013061080A1. 2013-05-02.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FGFR1; FGFR2; FGFR3; FGFR4
Frequently Asked Questions
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