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HPK1-IN-61

HPK1-IN-61 (Compound 1) is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) (Ki = 0.4 nM) and an inhibitor of Abl (IC50 LCK with an IC50 of 24 nM[1].

Product Specifications

CAS Number

875638-86-1

UNSPSC

12352005

Target

Bcr-Abl; MAP4K; Src

Related Pathways

MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Others

Smiles

NC1=C(C=C(C2=CN=C3NC=C(C3=C2)C4=C(OC)C=CC=C4)C=C1)C(N(C)C)=O

Molecular Formula

C23H22N4O2

Molecular Weight

386.45

References & Citations

[1]Chan, B. K., et al., (2021) . Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1) . ACS medicinal chemistry letters, 13 (1), 84–91.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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