CHNQD-01269

CHNQD-01269, a brefeldin A-cinnamate derivative, is an Arf1 inhibitor. CHNQD-01269 exhibits potent cytotoxic activity against HepG2 and BEL-7402 cells, with IC50 values of 0.29 and 0.84 μM, respectively. CHNQD-01269 is indicated for hepatocellular carcinoma (HCC) research[1].

Product Specifications

CAS Number

[2648988-92-3]

UNSPSC

12352005

Target

Arf Family GTPase

Related Pathways

GPCR/G Protein

Field of Research

Cancer

Smiles

CN(C)C(C=C1)=CC=C1/C=C/C(O[C@H]2[C@@]3([H])[C@@](/C=C/CCC[C@@H](OC(/C=C/2)=O)C)([H])C[C@@H](C3)O)=O

Molecular Formula

C27H35NO5

Molecular Weight

453.57

References & Citations

[1]Jiang YY, et al. New brefeldin A-cinnamic acid ester derivatives as potential antitumor agents: Design, synthesis and biological evaluation. Eur J Med Chem. 2022 Oct 5;240:114598.