CDD-1349

CDD-1349 (Compound 15) is a BRDT-BD2/BRD4-BD2 selective inhibitor. CDD-1349is an analog with sixfold selectivity for BRDT-BD2 versus BRD4-BD2. CDD-1349 has an IC50 of 22 nM against BRDT. CDD-1349 can be studied in research on nonhormonal contraceptive agent[1].

Product Specifications

CAS Number

[2757619-90-0]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Related Pathways

Epigenetics

Field of Research

Endocrinology

Smiles

O=C(C1=CC=C(C(NC)=O)C=C1)NC2=CC(NC(C3=CC(C(C4=C(C)C=C(N)N=C4)=NN5C)=C5C=C3)=O)=CC=C2C

Molecular Formula

C31H29N7O3

Molecular Weight

547.61

References & Citations

[1]Yu, Z., et al., (2021) . Discovery and characterization of bromodomain 2-specific inhibitors of BRDT. Proceedings of the National Academy of Sciences of the United States of America, 118 (9), e2021102118.