Simepdekinra
Simepdekinra (Compound 221) is a IL-17A modulator with IC50s ≤10 nM and 10-100 nM for IL-17A/A HEK-Blue and IL-17A/F HEK-Blue cells. Simepdekinra can be used for inflammatory diseases such as psoriasis, ankylosing spondylitis and psoriatic arthritis research[1].
Product Specifications
CAS Number
2978700-29-5
Product Name Alternative
LY4100511; DC-853
UNSPSC
12352005
Target
Interleukin Related
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Purity
98.10
Smiles
O=C(C1=CC=NN1CC)N[C@H](C(NC2=C(C=C(C=C2)[C@H](C)[C@@H](NC([C@H](C)OC)=O)C(N3C[C@H](N(CC3)C)C)=O)F)=O)C(C4CC4)C5CC5
Molecular Formula
C35H50FN7O5
Molecular Weight
667.81
References & Citations
[1]Church T J, et al. Di-cyclopropyl based il-17a modulators and uses thereof. WO2023164057A1. 2023-08-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-17
Available Sizes
Frequently Asked Questions
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