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Simepdekinra

Simepdekinra (Compound 221) is a IL-17A modulator with IC50s ≤10 nM and 10-100 nM for IL-17A/A HEK-Blue and IL-17A/F HEK-Blue cells. Simepdekinra can be used for inflammatory diseases such as psoriasis, ankylosing spondylitis and psoriatic arthritis research[1].

Product Specifications

CAS Number

2978700-29-5

Product Name Alternative

LY4100511; DC-853

UNSPSC

12352005

Target

Interleukin Related

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Purity

98.10

Smiles

O=C(C1=CC=NN1CC)N[C@H](C(NC2=C(C=C(C=C2)[C@H](C)[C@@H](NC([C@H](C)OC)=O)C(N3C[C@H](N(CC3)C)C)=O)F)=O)C(C4CC4)C5CC5

Molecular Formula

C35H50FN7O5

Molecular Weight

667.81

References & Citations

[1]Church T J, et al. Di-cyclopropyl based il-17a modulators and uses thereof. WO2023164057A1. 2023-08-31.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IL-17

Available Sizes

Frequently Asked Questions

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