Sebrinoflast
Sebrinoflast (Compound 5) is a NLRP3 inhibitor with an IC50 ≤1 μM for hNLRP3. Sebrinoflast can be used for inflammatory and cardiovascular diseases including NASH and atherosclerosis and neurological diseases like Alzheimer's disease research[1].
Product Specifications
CAS Number
[2919854-67-2]
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Smiles
OC(C=C(C=C1)C)=C1C2=NN=C(C3=C2C=CN=C3)N[C@@H]4CC(C)(OC4)C
Molecular Formula
C20H22N4O2
Molecular Weight
350.41
References & Citations
[1]DORICH S, et al. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives. US11618751B1. 2023-04-04.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
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