ZBP1 Covalent PROTAC-1

ZBP1 Covalent PROTAC-1 is a covalent Z-DNA binding protein 1 ZBP1 PROTAC degrader, with its DC50 being 25.69 nM. ZBP1 Covalent PROTAC-1 integrates the ligand that recruits the VHL E3 ubiquitin ligase and the DNA aptamer (Aptamer Z3) with the specific Zα domain that can bind to ZBP1, which has a high affinity (KD = 2.71 nM) with ZBP1. After degrading ZBP1, the phosphorylation levels of downstream signaling molecules RIPK3 and MLKL significantly decrease. ZBP1 Covalent PROTAC-1, encapsulated by nano-liposomes, significantly improves the survival rate of mice infected with influenza A virus (IAV) after administration via the trachea[1].

Product Specifications

UNSPSC

12352005

Target

Mixed Lineage Kinase; PROTACs; RIP kinase

Related Pathways

Apoptosis; MAPK/ERK Pathway; PROTAC

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Purity

96.87

Smiles

O=C(CCCCC(N(CC#N)S(=O)(C1=CC=C(C=C1)CCS[3'-AAGTGCCATCGTGCGTATCCCTCGCGTCTGCTTGCTCGTCCCAACCCACCACCGCCCGATACGCACCTCACGACTT-5'])=O)=O)N2C3=C(C4=C(C5=C(C2)C=CC=C5)N(CCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N6C[C@@H](C[C@H]6C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)O)=O)=O)N=N4)C=CC=C3

Molecular Weight

24590.00

References & Citations

[1]Huang R, et al. Targeted Degradation of ZBP1 with Covalent PROTACs for Anti-Inflammatory Treatment of Infections. Angew Chem Int Ed Engl. 2025 May;64 (19) :e202423524.