Mesutoclax
Mesutoclax (ICP-248) (Compound 5) is a selective BCL-2 inhibitor with an IC50 of 1.54 nM. Mesutoclax has weak activity against BCL-XL (IC50: > 1000 nM) . Mesutoclax can inhibit the activity of RS4;11 cells with an IC50 of 2.75 nM. Mesutoclax can be used in the study of cancer[1].
Product Specifications
CAS Number
[2760536-87-4]
Product Name Alternative
ICP-248
UNSPSC
12352005
Target
Bcl-2 Family
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC(C)(CC1)CC(C2=CC=C(C=C2)Cl)=C1CN3[C@@H](CN(C4=CC(OC5=CN=C(NC=C6)C6=C5)=C(C=C4)C(NS(=O)(C7=CC([N+]([O-])=O)=C(C=C7)NC[C@H]8COCCO8)=O)=O)CC3)C
Molecular Formula
C45H50ClN7O8S
Molecular Weight
884.44
References & Citations
[1]Kong XL, Heterocyclic compound as bcl-2 inhibitor. WO2022028353A1. 2022-02-10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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