Lotixparib

Lotixparib (Example 1) is an inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1) . Lotixparib has cytoprotective effect against a retinal disease. Lotixparib can be studied in research for PARP-1-associated diseases[1].

Product Specifications

CAS Number

[2640677-63-8]

UNSPSC

12352005

Target

PARP

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Others

Smiles

N#CC1=CC=C(N2CCN(CCCC3=CC4=C(C(N3)=O)C(F)=CC=C4)CC2)C=C1

Molecular Formula

C23H23FN4O

Molecular Weight

390.45

References & Citations

[1]Eunhee Kim, et al., Isoquinolinone derivative, preparation method therefor, and pharmaceutical composition, comprising same as active ingredient, for prevention or treatment of poly (adp-ribose) polymerase-1 (parp-1) -associated disease. WO2021086077A1.