Fumiporexant
Fumiporexant (Compound Example 93) is an orally active, brain-penetrant and selective Orexin receptor 2 (OX2R) antagonist. Fumiporexant regulates the sleep-wake cycle and emotion-related pathways in the central nervous system. Fumiporexant is promising for research of nervous system diseases such as insomnia and major depressive disorder[1].
Product Specifications
CAS Number
2839408-03-4
UNSPSC
12352005
Target
Orexin Receptor (OX Receptor)
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(N1C[C@]2([H])[C@](CN(C3=NC=C(F)C(C(C)(O)C)=N3)C2)([H])C1)C4=C(C5=NC=CC=N5)C=CC=C4F
Molecular Formula
C24H24F2N6O2
Molecular Weight
466.48
References & Citations
[1]Xiao HL, et al. Nitrogen-containing heterocyclic polycyclic compound, preparation method therefor, and application thereof. WO2022194122A1. 2022-09-22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
OX2 Receptor
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