Fumiporexant

Fumiporexant (Compound Example 93) is an orally active, brain-penetrant and selective Orexin receptor 2 (OX2R) antagonist. Fumiporexant regulates the sleep-wake cycle and emotion-related pathways in the central nervous system. Fumiporexant is promising for research of nervous system diseases such as insomnia and major depressive disorder[1].

Product Specifications

CAS Number

[2839408-03-4]

UNSPSC

12352005

Target

Orexin Receptor (OX Receptor)

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(N1C[C@]2([H])[C@](CN(C3=NC=C(F)C(C(C)(O)C)=N3)C2)([H])C1)C4=C(C5=NC=CC=N5)C=CC=C4F

Molecular Formula

C24H24F2N6O2

Molecular Weight

466.48

References & Citations

[1]Xiao HL, et al. Nitrogen-containing heterocyclic polycyclic compound, preparation method therefor, and application thereof. WO2022194122A1. 2022-09-22.