IL-6-IN-2
IL-6-IN-2 (Compound 15) is an inhibitor of the IL-6/IL-6R protein interaction. The ∆G binding energy of IL-6-IN-2 is −36.50 kcal/mol. Contributions of Lys66, Phe74, Gln175, Ser176, and Arg179 to IL-6 binding are −1.10, −8.68, −6.91, −3.69, and −1.72 kcal/mol, respectively. IL-6-IN-2 exhibits low gastrointestinal (GI) absorption[1].
Product Specifications
CAS Number
296790-70-0
UNSPSC
12352005
Target
Interleukin Related
Related Pathways
Immunology/Inflammation
Field of Research
Others
Purity
99.95
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
OC1=C(C(C2=C(N(C3=CC=CC=C3)N=C2C)O)C4=CC=C(C)O4)C(C)=NN1C5=CC=CC=C5
Molecular Formula
C26H24N4O3
Molecular Weight
440.49
References & Citations
[1]Zia K, et al. Taming the cytokine storm: small molecule inhibitors targeting IL-6/IL-6α receptor. Mol Divers. 2024 Dec;28 (6) :4151-4165.Zia K, et al. Taming the cytokine storm: small molecule inhibitors targeting IL-6/IL-6α receptor. Mol Divers. 2024 Dec;28 (6) :4151-4165.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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