Nitrobenzylthioinosine 5'-monophosphate
Nitrobenzylthioinosine 5'-monophosphate (NBMPR-P), a nucleoside analog, is a prodrug of the potent nucleoside transport inhibitor Nitro-benzylthioinosine (NBMPR) (HY-W010936) . Nitrobenzylthioinosine 5'-monophosphate blocks nucleoside transport in vivo and prevents host toxicity in tumor-bearing mice administered with highdoses of Tubercidin (HY-100126) [1][2].
Product Specifications
CAS Number
[65199-10-2]
Product Name Alternative
NBMPR-P
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N(C=N2)C3=C2C(SCC4=CC=C([N+]([O-])=O)C=C4)=NC=N3
Molecular Formula
C17H18N5O9PS
Molecular Weight
499.39
References & Citations
[1]Patel DH, et al. Retroviral transfer of the hENT2 nucleoside transporter cDNA confers broad-spectrum antifolate resistance in murine bone marrow cells. Blood. 2000 Apr 1;95 (7) :2356-63.|[2]el Kouni MH, et al. Combination therapy of schistosomiasis by tubercidin and nitrobenzylthioinosine 5'-monophosphate. Proc Natl Acad Sci U S A. 1983 Nov;80 (21) :6667-70.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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