KAT6A/KAT7-IN-3
KAT6A/KAT7-IN-3 (Example 191) is a KAT6A and KAT7 inhibitor. The IC50 of KAT6A/KAT7-IN-3 for KAT6A is ≤ 50 nM and > 10 nM, while the IC50 for KAT7 is ≤ 1 nM. KAT6A/KAT7-IN-3 can inhibit the acetylation of H3K14 and H3K23. KAT6A/KAT7-IN-3 also inhibits tumor cell proliferation, with an IC50 of > 2 μM and ≤ 5 μM for CAMA-1. KAT6A/KAT7-IN-3 can be used in the study of cancer[1].
Product Specifications
CAS Number
3092066-83-3
UNSPSC
12352005
Target
Histone Acetyltransferase
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=S(C1=C(OC)C=CN=C1OC)(NC2=NOC3=C2CC4(C5=C3C=C(N6C(CCC6)=O)C=C5)CC4)=O
Molecular Formula
C24H24N4O6S
Molecular Weight
496.54
References & Citations
[1]Brian Thomas Jones, et al. Chemical compounds and uses thereof. WO2025136811A1. 2025-06-26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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