Tubulin-IN-51

Tubulin-IN-51 is an orally available, potent tubulin inhibitor (IC50 = 31 nM) . Tubulin-IN-51 promotes tubulin polymerization in vitro and does not compete with Paclitaxel (HY-B0015) for binding. Tubulin-IN-51 inhibits the binding of Vinblastine (HY-13780) to tubulin. Tubulin-IN-51 downregulates the proportion of cells in the G1 phase and induces apoptosis. Tubulin-IN-51 inhibits tumor growth in multiple nude mouse xenograft models[1].

Product Specifications

CAS Number

[849550-36-3]

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

FC1=CC(OCCCNC)=CC(F)=C1C2=C(N[C@@H](C(F)(F)F)C)N3N=CN=C3N=C2Cl

Molecular Formula

C18H18ClF5N6O

Molecular Weight

464.82

References & Citations

[1]Zhang N, et al. Synthesis and SAR of [1,2,4]triazolo[1,5-a]pyrimidines, a class of anticancer agents with a unique mechanism of tubulin inhibition. J Med Chem. 2007 Jan 25;50 (2) :319-27.