Exatecan-mpGNNG

Exatecan-mpGNNG (Compound 10a) is the linker-payload component of an antibody-drug conjugate (ADC) . Exatecan-mpGNNG is composed of Exatecan (HY-13631), a potent topoisomerase I inhibitor, and the linker[1].

Product Specifications

CAS Number

[3076725-05-5]

UNSPSC

12352211

Target

Drug-Linker Conjugates for ADC

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(C=CC1=O)N1CCC(NCC(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O)=O)=O)=O

Molecular Formula

C43H45FN10O13

Molecular Weight

928.88

References & Citations

[1]Ojo VT, et al. Legumain-Cleavable Top1i Antibody-Drug Conjugates without Self-Immolative Spacers Demonstrate Potent Antitumor Activity. J Med Chem. 2025 Nov 20.