Exatecan-mpGNNG
Exatecan-mpGNNG (Compound 10a) is the linker-payload component of an antibody-drug conjugate (ADC). Exatecan-mpGNNG is composed of Exatecan , a potent topoisomerase I inhibitor, and the linker[1].
Product Specifications
CAS Number
3076725-05-5
UNSPSC
12352211
Target
Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C=CC1=O)N1CCC(NCC(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O)=O)=O)=O
Molecular Formula
C43H45FN10O13
Molecular Weight
928.88
References & Citations
[1]Ojo VT, et al. Legumain-Cleavable Top1i Antibody-Drug Conjugates without Self-Immolative Spacers Demonstrate Potent Antitumor Activity. J Med Chem. 2025 Nov 20.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Frequently Asked Questions
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