DRP1 Allosteric-IN-3

DRP1 Allosteric-IN-3 (Compound 2b) is an allosteric inhibitor of DRP1. Its IC50 value for the DRP1:MiD49 protein-protein interaction is 11 μM. DRP1 Allosteric-IN-3 can be used to study various diseases related to mitochondrial division disorders[1].

Product Specifications

CAS Number

[3056559-92-0]

UNSPSC

12352005

Target

Dynamin

Related Pathways

Cytoskeleton

Field of Research

Cancer; Metabolic Disease; Neurological Disease; Cardiovascular Disease

Smiles

O=C(C(C)C)NC1=CC2=C(N=C(C3=CC=CC=C3)C=C2N(C)C)C=C1

Molecular Formula

C21H23N3O

Molecular Weight

333.43

References & Citations

[1]Staben LR, et al. Systematic Variation of Pyrrolobenzodiazepine (PBD) -Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates. J Med Chem. 2020 Sep 10;63 (17) :9603-9622.