Di (MMY-SJG) -Ph-prop-2-yne-1-sulfonic acid

Di (MMY-SJG) -Ph-prop-2-yne-1-sulfonic acid (Compound 5) is a cytotoxic pyrrolobenzodiazepine (PBD) dimer derivative. Di (MMY-SJG) -Ph-prop-2-yne-1-sulfonic acid exhibits moderate DNA alkylating activity. Di (MMY-SJG) -Ph-prop-2-yne-1-sulfonic acid can be used as the payload of ADC, thereby demonstrating strong antigen-dependent cytotoxicity[1].

Product Specifications

CAS Number

[3037777-07-1]

UNSPSC

12352005

Target

ADC Payload; DNA/RNA Synthesis

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1C2=CC(OC)=C(OCC3=CC(COC4=C(C=C5C(N=C[C@@]6([H])N(CC(C6)=C)C5=O)=C4)OC)=CC(C#CCS(=O)(O)=O)=C3)C=C2N=C[C@@]7([H])N1CC(C7)=C

Molecular Formula

C39H36N4O9S

Molecular Weight

736.79

References & Citations

[1]Staben LR, et al. Systematic Variation of Pyrrolobenzodiazepine (PBD) -Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates. J Med Chem. 2020 Sep 10;63 (17) :9603-9622.